Thermo Fisher Scientific TRPC3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitution:
  Reconstitute with 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
  The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at −20°C.
  The reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and store at −20°C.
  Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

The mammalian transient receptor potential (TRP) superfamily can be divided into three major families, including the canonical TRP (TRPC) family.
The seven members of this family share activation through PLC-coupled receptors and are suggested to be components of receptor-regulated cation channels in various cell types.
Members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a mechanism of activation via PLC-coupled receptors.
TRPC3 encodes a Ca²⁺-permeant channel that is agonist-activated but not store-operated or directly receptor-activated.
TRPC3 interacts with TRPC6 and TRPC7 to form functional tetrameric channels.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.