Thermo Fisher Scientific KLRB1 Monoclonal Antibody (2F3)
Human KLRB1(CD161)에 특이적인 Mouse monoclonal antibody(2F3)로 Western blot 및 ELISA에 적합. Unconjugated 형태, PBS buffer 내 액상 제품이며 -20°C에서 보관. NK 및 T세포 표면항원 연구용으로 사용.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 0.1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F3 |
| Immunogen | KLRB1 (NP_002249, 126–225 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ESSLLLIRDK DELIHTQNLI RDKAILFWIG LNFSLSEKNW KWINGSFLNS NDLEIRGDAK ENSCISISQT SVYSEYCSTE IRWICQKELT PVRNKVYPDS
Target Information
KLRB1 (Killer cell lectin-like receptor subfamily B, member 1, CD161) is a type II membrane protein with an external C terminus. It is expressed on nearly all NK cells and a subset of CD3⁺ T cells.
KLRB1 forms a homodimeric cell surface protein (40–44 kDa) and plays an inhibitory role in NK cell activity. Activation of KLRB1 stimulates acid sphingomyelinase/SMPD1 and increases intracellular ceramide, leading to AKT1/PKB and RPS6KA1/RSK1 kinase activation and T cell proliferation.
KLRB1 acts as a lectin binding to Gal-α(1,3)Gal and N-acetyllactosamine epitopes, as well as CLEC2D/LLT1 ligand, thereby inhibiting NK cell-mediated cytotoxicity and interferon-γ secretion.
The protein includes an extracellular domain with C-type lectin motifs, a transmembrane domain, and a cytoplasmic domain.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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