Thermo Fisher Scientific IREB2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human IREB2. Recombinant protein control fragment (Product #RP-104254). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IREB2,uniProtId:P48200-1,ncbiNodeId:9606,antigenRange:377-448,antigenLength:963,antigenImageFileName:PA5-64388_IREB2_P48200-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64388_IREB2_P48200-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642774

Product Specific Information

Immunogen sequence: EYGAILSFFP VDNVTLKHLE HTGFSKAKLE SMETYLKAVK LFRNDQNSSG EPEYSQVIQI NLNSIVPSVS GP

Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.

Target Information

Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.