Thermo Fisher Scientific BCCIP Polyclonal Antibody
BCCIP 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot과 IHC(Paraffin)에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 항원 친화 크로마토그래피로 정제된 고순도 제품입니다. BRCA2 및 p21 단백질 상호작용 연구에 활용됩니다.
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Thermo Fisher Scientific BCCIP Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human BCCIP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720151 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
The BCCIP gene product interacts with BRCA2 and p21 proteins and is an evolutionarily conserved nuclear protein with multiple interacting domains.
The N-terminal region shares homology with calmodulin and M-calpain, suggesting calcium-binding capability.
Functionally, BCCIP may serve as a cofactor for BRCA2 in tumor suppression and modulate CDK2 kinase activity via p21.
It plays roles in BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression.
Multiple transcript variants encoding different isoforms have been described for this gene.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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