Thermo Fisher Scientific ZNF198 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse and Orangutan

Target Information

ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of five N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain, and a C-terminal nuclear localization signal (NLS) with an acidic domain.
Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of the ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase that regulates STAT transcription factors including STAT1, STAT3, and STAT5.
The fusion protein is oncogenic and associated with atypical myeloproliferative disease, peripheral blood eosinophilia, and T-cell leukemia/lymphoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.