
Thermo Fisher Scientific DGKQ Polyclonal Antibody
Human DGKQ 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, IHC(P)에서 1:20~1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 핵 내 DAG 신호 조절 연구에 적합.
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Applications
Tested Applications and Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DGKQ. Recombinant protein control fragment (Product #RP-102422). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640552 |
Product Specific Information
Immunogen sequence:
HVSLFVGGLP PGLSPEEYSS LLHEAGATKA TVVSVSHIYS SQGAVVLDVA CFAEAERLYM LLKDMAVRGR LLTALVLPDL LHAKLPPDSC PLLVFVNPKS G
Highest antigen sequence identity to orthologs:
- Mouse: 82%
- Rat: 84%
Target Information
Diacylglycerol (DAG) is a fundamental lipid second messenger produced in the nucleus. The accumulation of DAG regulates cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, reducing protein kinase C activity and controlling T lymphocyte cell cycle progression.
DGK-theta is a Type V DGK that localizes mainly to the nucleus of various cell lines (MDA-MB-453, MCF-7, PC12, HeLa) and co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)). DGK-theta responds to alpha-Thrombin stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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