Thermo Fisher Scientific CD44/HCAM Std (Cancer Stem Cell Marker) Recombinant Rabbit Monoclonal Antibody (HCAM/6459R)
CD44/HCAM 표지 단백질을 인식하는 재조합 토끼 단일클론 항체로, 암 줄기세포 마커 연구에 적합합니다. 인간 시료 반응성이 있으며, IHC(P)와 IHC(PFA) 적용 가능. 고순도 Protein A/G 정제, PBS 버퍼 저장, 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HCAM/6459R |
| Immunogen | Recombinant full-length human CD44 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 acts as a receptor for hyaluronic acid (HA) and is involved in:
- Cell-cell interactions
- Cell adhesion and migration
- Lymphocyte activation, recirculation, and homing
CD44 expression may be upregulated in some carcinomas, potentially related to metastatic potential. It is highly expressed in bone marrow myeloid cells and memory T cells, and peripheral B and T cells can upregulate CD44 in response to stimulation.
Transcripts of the CD44 gene undergo complex alternative splicing, creating functionally distinct isoforms. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be linked to tumor metastasis formation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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