Thermo Fisher Scientific TAF6 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
LSDIINTPLP RVPLDVCLKA HWLSIEGCQP AIPENPPPAP KEQQKAEATE PLKSAKPGQE EDGPLKGKGQ GATTADGKGK EKKAPPLLEG APLRLKPRSI HELSVEQQLY YKEITEACVG SCEAKRAEAL QSIATDPG

Ortholog sequence identity:

• Mouse: 98%
• Rat: 98%

Target Information

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.
TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors (TAFs).
TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition, or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.
This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID.
Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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