Thermo Fisher Scientific JTB Polyclonal Antibody
Human JTB 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 세포 분열 및 미토콘드리아 기능 연구에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human JTB. Recombinant protein control fragment (Product #RP-89171) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642862 |
Product Specific Information
Immunogen sequence:
EEKLSASTSN LPCWLVEEFV VAEECSPCSN FRAKTTPECG PTGYVEKITC SSSKRNEFKS CRSALMEQRL
Highest antigen sequence identity to the following orthologs:
- Mouse: 84%
- Rat: 86%
Target Information
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a key regulator of mitosis. The CPC complex functions at the centromere to ensure correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity and inhibits apoptosis induced by TGFB1. Overexpression induces mitochondrial swelling and reduces mitochondrial membrane potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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