Thermo Fisher Scientific CD15 Monoclonal Antibody (MCS-1), FITC

Applications

• Flow Cytometry (Flow): 10 µL / 1×10⁶ cells

Product Specifications

Product Specific Information

This monoclonal anti-CD15 antibody is an IgG3 fraction which will not agglutinate cells, unlike most IgM antibodies that cause cell aggregation in the cytometer.

Target Information

CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisaccharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins, and proteoglycans of various cell types such as granulocytes, mast cells, monocytes, macrophages, gastric mucosa cells, nervous system cells, and tumor cells.
Variants include sialyl-Lewis x and sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation via calcium-dependent Le(x)-Le(x) interaction, involved in embryo compaction and teratocarcinoma cell autoaggregation.
Sialyl-Le(x) and its isomer sialyl-Le(a) act as selectin ligands. CD15 expression is widely used to confirm the diagnosis of Hodgkin’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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