Thermo Fisher Scientific CD1d Monoclonal Antibody (1B1), Biotin, eBioscience
Mouse CD1d를 인식하는 Rat IgG2b 단클론 항체로, Biotin으로 표지됨. Flow Cytometry에 최적화되어 있으며 1 µg/test 권장. 0.5 mg/mL 농도의 액상 제품으로 PBS buffer에 보존. 연구용으로 사용, 진단용 불가.
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Thermo Fisher Scientific CD1d Monoclonal Antibody (1B1), Biotin, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Flow Cytometry (Flow) | 1 µg/test | View 8 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Recommended Isotype Control | Rat IgG2b kappa Isotype Control (eB149/10H5), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466308 |
Additional Formats Available
- Unconjugated
- Alexa Fluor 488
- APC
- Brilliant Violet 480
- Brilliant Violet 711
- eFluor 450
- Functional Grade
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Red 700
- NovaFluor Red 755
- NovaFluor Yellow 610
- NovaFluor Yellow 660
- NovaFluor Yellow 700
- NovaFluor Yellow 755
- PE
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
Description:
The 1B1 monoclonal antibody reacts with mouse CD1d, a 48 kDa glycoprotein structurally homologous to MHC class I molecules. Although similar in structure to MHC Class I, CD1d associates with β2-microglobulin and functionally resembles MHC Class II. The 1B1 antibody detects CD1d at varying levels on mouse leukocytes and specifically recognizes β2m-associated CD1d.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Tested by flow cytometric analysis of mouse splenocytes. Recommended use ≤1 µg per test (100 µL final volume). Cell numbers can range from 10⁵ to 10⁸ cells/test. Antibody titration is advised for optimal performance.
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
CD1d is a heavy chain associated with β2-microglobulin on cortical thymocytes. Independent expression of CD1d has been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of MHC-like glycoproteins.
The CD1d gene encodes a transmembrane glycoprotein structurally related to MHC proteins, forming heterodimers with β2-microglobulin. CD1 proteins present lipid and glycolipid antigens to T cells. The human genome contains five CD1 family genes clustered on chromosome 1, differing in localization and ligand specificity. CD1d localizes to late endosomes and lysosomes via a tyrosine-based motif.
Diseases associated with CD1D include Mycobacterium Malmoense infection and autoimmune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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