Thermo Fisher Scientific KIR2DL4 Monoclonal Antibody (4C2D11)
인간 KIR2DL4 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, Flow cytometry, ELISA에 사용 가능. 1 mg/mL 농도의 액상 형태이며 Protein G로 정제됨. 단기 보관은 4°C, 장기 보관은 -20°C에서 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C2D11 |
| Immunogen | Purified recombinant fragment of human CD158D (aa: extra 22–120) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898384 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains a cytoplasmic ITIM, suggesting inhibitory function, but also a transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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