Thermo Fisher Scientific GM-CSF Monoclonal Antibody (6804)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 0.25 µg per million cells

ELISA (ELISA)

• Detection: 0.5–2 µg/mL
• Capture: 2–8 µg/mL

Product Specifications

Product Specific Information

• In ELISAs, this antibody does not cross-react with recombinant mouse (rm) GM-CSF, rrGM-CSF, rhM–CSF, rhG-CSF, rhIL-5-R alpha, or rhIL-3 R alpha.
• Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

The GM-CSF gene encodes a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space.
This gene is located in a cluster of related genes at chromosome region 5q31, associated with interstitial deletions in 5q-syndrome and acute myelogenous leukemia. Other genes in this cluster include interleukins 4, 5, and 13.
The gene promotes tissue inflammation, and elevated cytokine levels have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice lacking this gene or its receptor develop pulmonary alveolar proteinosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.