Thermo Fisher Scientific GM-CSF Monoclonal Antibody (6804)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.25 µg per million cells

-

ELISA (ELISA)

0.5-2 µg/mL (Detection), 2-8 µg/mL (Capture)

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

6804

Immunogen

E. coli-derived recombinant human GM-CSF Ala18-Glu144 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GM-CSF,uniProtId:P04141-1,ncbiNodeId:9606,antigenRange:18-144,antigenLength:144,antigenImageFileName:MA5-23699_GM-CSF_P04141-1_House_mouse.svg,antigenImageFileNamePDP:MA5-23699_GM-CSF_P04141-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609756

Product Specific Information

In ELISAs, this antibody does not cross-react with recombinant mouse (rm) GM-CSF, rrGM-CSF, rhM–CSF, rhG-CSF, rhIL-5-R alpha, or rhIL-3 R alpha.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.