Thermo Fisher Scientific Catenin beta Monoclonal Antibody (ZY480)
Human beta-catenin을 인식하는 Mouse monoclonal antibody(ZY480). Western blot 및 IHC(P) 검증 완료. 세포 내 β-catenin 발현 및 위치 분석에 적합. Protein A 정제, PBS buffer에 보존, 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ZY480 |
| Immunogen | A synthetic peptide of human beta-catenin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human lung adenocarcinoma
- Cellular location: Cytoplasm, Nucleus
Target Information
Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for forming and maintaining epithelial cell layers by regulating cell growth and adhesion. Beta-catenin interacts with the cytoplasmic domain of E-cadherin, linking it to alpha-catenin, which anchors the E-cadherin complex to the cortical actin cytoskeleton.
Additionally, beta-catenin binds to cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways, including tyrosine kinases, phosphatases, and Wnt/Wingless pathways. These interactions regulate morphogenesis and cell proliferation.
Beta-catenin is expressed in multiple hair follicle cell types and epithelial cells. Dysregulation has been implicated in various cancers, including pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, stimulating genes such as cyclin D and c-myc that promote cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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