Thermo Fisher Scientific BCR Polyclonal Antibody
인간 BCR 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 0.25 mg/mL 농도의 액상 형태. TBS 버퍼(pH 7.0–8.0, 0.1% BSA 포함)에 보관하며, 4°C에서 안정적으로 저장 가능.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 50 and 100 of human breakpoint cluster region |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Gorilla
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia.
The chromosome 22 breakpoint for this translocation is located within the BCR gene.
This translocation produces a fusion protein encoded by sequences from both BCR and ABL (chromosome 9 breakpoint).
Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product remains unclear.
The BCR protein has serine/threonine kinase activity and acts as a GTPase-activating protein for p21rac.
Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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