Thermo Fisher Scientific QKI Polyclonal Antibody
QKI 단백질을 표적으로 하는 Thermo Fisher Scientific의 염소 폴리클로날 항체로, Western blot에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 0.5 mg/mL 농도의 액상 형태입니다. 다양한 종에서 교차 반응이 예측되며 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (ETKEKPKPTPDY) corresponding to the N-terminus amino acids of QKI (aa 6–18) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983490 |
Product Specific Information
- This antibody is predicted to react with bovine, canine, human, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles, and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin has been found to protect against mutant ataxin-1. A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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