Thermo Fisher Scientific ZEB2 Polyclonal Antibody
ZEB2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC에 적합합니다. Human 및 Mouse 시료에 반응하며, Affinity Chromatography로 정제되었습니다. PBS buffer에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (IHC) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human ZFHX1B (aa 30–79) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2610187 |
Product Specific Information
Peptide sequence:
NVVDTGSETD EEDKLHIAED DGIANPLDQE TSPASVPNHE SSPHVSQALL
Sequence homology:
Cow: 86%
Dog: 93%
Guinea Pig: 100%
Horse: 93%
Human: 100%
Mouse: 93%
Rabbit: 100%
Rat: 100%
Yeast: 75%
Zebrafish: 75%
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is a nuclear DNA-binding transcriptional repressor that interacts with activated SMADs. Like ZEB1, it inhibits E-cadherin transcription and induces epithelial-mesenchymal transition (EMT), regulating cell migration during embryonic development and wound healing. ZEB2 also protects cells from DNA damage-induced apoptosis, potentially contributing to tumor progression. It is often observed in the cytoplasm of various cancer tissues, suggesting regulated localization. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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