Thermo Fisher Scientific Phospho-MCK10 (Tyr513) Polyclonal Antibody
인산화된 MCK10(Tyr513)을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF, ELISA 등에 적합합니다. 고순도 Protein A 정제, 1 mg/mL 농도, -20°C 보관 조건을 갖춘 연구용 항체입니다.
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Thermo Fisher Scientific Phospho-MCK10 (Tyr513) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human MCK10 around the phosphorylation site of Tyr513 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration, and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment and are involved in the regulation of cell growth, differentiation, and metabolism.
The protein encoded by this gene is a RTK widely expressed in normal and transformed epithelial cells and activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain.
Autophosphorylation is achieved by all collagens tested (type I to type VI). Expression is restricted to epithelial cells, particularly in kidney, lung, gastrointestinal tract, and brain. Overexpression is observed in several human tumors including breast, ovarian, esophageal, and pediatric brain cancers. The gene is located on chromosome 6p21.3 near several HLA class I genes, and alternative splicing results in multiple transcript variants.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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