Thermo Fisher Scientific Human TNFAIP3 Synthetic Peptide
인간 TNFAIP3 단백질의 C-말단 14개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-20728과 함께 블로킹 펩타이드로 사용 가능. 정제된 액상 형태로 제공되며, PBS 완충액에 0.1% BSA와 0.02% sodium azide를 포함. 연구용 전용 시약.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human TNFAIP3.
PEP-0842 can be used as a blocking peptide with polyclonal antibody PA5-20728.
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. It has been identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas.
TNFAIP3 encodes a zinc-finger protein rapidly induced by TNF-α, inhibiting NF-κB-dependent gene expression and protecting cells from TNF-α cytotoxicity. Overexpression of TNFAIP3 also inhibits TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting its role as a negative regulator of TLR-mediated inflammatory responses and protection against excessive immune reactions.
At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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