Thermo Fisher Scientific PDE8A Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PDE8A. Recombinant protein control fragment (Product #RP-95154). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PDE8A,uniProtId:O60658-1,ncbiNodeId:9606,antigenRange:246-380,antigenLength:829,antigenImageFileName:PA5-82311_PDE8A_O60658-1_Rabbit.svg,antigenImageFileNamePDP:PA5-82311_PDE8A_O60658-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2789470

Product Specific Information

Immunogen sequence: TTMGYQSGEL IGKELGEVPI NEKKADLLDT INSCIRIGKE WQGIYYAKKK NGDNIQQNVK IIPVIGQGGK IRHYVSIIRV CNGNNKAEKI SECVQSDTHT DNQTGKHKDR RKGSLDVKAV ASRATEVSSQ RRHSS

Target Information

Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.