Thermo Fisher Scientific PDE8A Polyclonal Antibody
Human PDE8A에 특이적인 Rabbit Polyclonal Antibody로 IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상형 항체. PBS/40% glycerol buffer에 보관하며, 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Concentration: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PDE8A. Recombinant protein control fragment (Product #RP-95154) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789470 |
Product Specific Information
Immunogen sequence:
TTMGYQSGEL IGKELGEVPI NEKKADLLDT INSCIRIGKE WQGIYYAKKK NGDNIQQNVK IIPVIGQGGK IRHYVSIIRV CNGNNKAEKI SECVQSDTHT DNQTGKHKDR RKGSLDVKAV ASRATEVSSQ RRHSS
Target Information
Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides act as second messengers in various physiological processes such as vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction.
PDEs are divided into 10 families and differ in structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to inhibitors. Their diversity makes PDEs promising pharmacological targets for diseases influenced by cyclic nucleotide signaling (Hetman et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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