Thermo Fisher Scientific CD45 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human CD45, suitable for WB, IHC(P), and IP. Detects CD45 isoforms involved in immune cell signaling. Supplied as liquid, stored at -20°C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human CD45 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902823 |
Target Information
CD45 (also known as LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. It is absent in non-hematopoietic cell lines and tissues.
This glycoprotein plays a critical role in lymphocyte development and antigen signaling, acting as a regulator of Src-family kinases. Multiple CD45 isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic domains.
CD45RA, one of the isoforms, shows restricted expression among lymphoid cell subtypes. Isoform expression depends on cell type and physiological state. CD45 regulates T- and B-cell antigen receptor signaling, suppresses JAK kinases to control cytokine receptor signaling, and supports cell survival by modulating integrin-mediated signaling and apoptosis-related pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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