Thermo Fisher Scientific HOXB4 Monoclonal Antibody (3A2F2)
HOXB4 단백질을 인식하는 Mouse monoclonal 항체로, WB, IHC(P), ELISA에 적합합니다. 인간 시료에 반응하며 Protein G로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A2F2 |
| Immunogen | Purified recombinant fragment of human HOXB4 (AA: 16–251) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787391 |
Product Specific Information
MA5-31768 has been tested in indirect ELISA.
Target Information
HOX homeobox genes play a role both in early stem cell function and in later stages of hematopoietic differentiation.
HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive hematopoietic stem cells (HSCs).
Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induces a switch to the definitive HSC phenotype.
Activation of WNT signaling in HSCs increases expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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