Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43), FITC

Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43), FITC

Applications

• Flow Cytometry (Flow): 20 µL/1×10⁶ cells
• View 2 publications

Product Specifications

Additional Formats Available:

• Unconjugated
• Alexa Fluor 647
• APC
• Biotin
• PE
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with a well-defined epitope (W40, R-53) on CD59 (Protectin), an 18–20 kDa GPI-anchored glycoprotein expressed on the surface of all hematopoietic cells and widely present across tissues.
It does not compete with MEM-43/5 and exhibits blocking activity.

Target Information

CD59 (Protectin) is a small (18–20 kDa) GPI-anchored inhibitor of the membrane attack complex (MAC), ubiquitously expressed across tissues.
It preserves autologous cells from complement-mediated lysis by binding complement C8 and/or C9 during MAC assembly, preventing pore formation.
Additionally, CD59 acts as a low-affinity ligand of human CD2, contributing to T cell costimulation and lymphocyte signaling.
Mutations in CD59 can lead to deficiency associated with hemolytic anemia, thrombosis, and cerebral infarction.
Multiple alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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