Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43), FITC
인간 CD59 단백질을 인식하는 Mouse IgG2a 모노클로날 항체로 FITC 형광 표지. Flow Cytometry에 적합하며, PBS/BSA 완충액에 보관. 4°C 암소 저장, 면역세포 표면 CD59 검출에 활용.
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Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43), FITC
Applications
- Flow Cytometry (Flow): 20 µL/1×10⁶ cells
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-43 |
| Immunogen | Thymocytes and T lymphocytes |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073161 |
Additional Formats Available:
- Unconjugated
- Alexa Fluor 647
- APC
- Biotin
- PE
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with a well-defined epitope (W40, R-53) on CD59 (Protectin), an 18–20 kDa GPI-anchored glycoprotein expressed on the surface of all hematopoietic cells and widely present across tissues.
It does not compete with MEM-43/5 and exhibits blocking activity.
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored inhibitor of the membrane attack complex (MAC), ubiquitously expressed across tissues.
It preserves autologous cells from complement-mediated lysis by binding complement C8 and/or C9 during MAC assembly, preventing pore formation.
Additionally, CD59 acts as a low-affinity ligand of human CD2, contributing to T cell costimulation and lymphocyte signaling.
Mutations in CD59 can lead to deficiency associated with hemolytic anemia, thrombosis, and cerebral infarction.
Multiple alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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