Thermo Fisher Scientific Ubinuclein 2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Ubinuclein 1/2. Recombinant protein control fragment (Product #RP-92771).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649193

Product Specific Information

Immunogen sequence: SVTNQNVTPF GMLGGLVPVT MPFQFPLEIF GFGTDTAGVT TTSGSTSAAF HHSLTQNLLK GLQPGGAQHA ATLSHSPLPA HLQQAFHDGG QSKGDTKLPR KS

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 87%.

Target Information

Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.