Thermo Fisher Scientific POMC Monoclonal Antibody (OTI2B2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The POMC gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific post-translational processing by prohormone convertases. It contains eight potential cleavage sites, producing up to ten biologically active peptides depending on tissue type. These peptides play roles in steroidogenesis, energy homeostasis, melanocyte stimulation, and immune modulation.
POMC is mainly synthesized in corticotroph cells of the anterior pituitary, yielding adrenocorticotrophin and beta-lipotropin as major end products. Mutations in this gene are associated with early-onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.