Thermo Fisher Scientific BRD7 Polyclonal Antibody
BRD7 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot과 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. 동결건조 형태로 공급되며, 재구성 시 500 µg/mL 농도. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human BRD7 recombinant protein (Position: T514–R567) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2746000 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
BRD7 acts both as a coactivator and as a corepressor. It activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating GSK3B phosphotransferase activity. Additionally, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, facilitating efficient recruitment of TP53 to target promoters and inhibiting cell cycle progression from G1 to S phase.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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