Thermo Fisher Scientific AMOTL2 Polyclonal Antibody
AMOTL2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA에 사용 가능. 인간 및 생쥐 반응성. 고순도 Affinity Chromatography 정제, 액상 형태로 안정적이며 연구용으로 적합.
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Thermo Fisher Scientific AMOTL2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 638–837 of human AMOTL2 (NP_001265612.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.46 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914053 |
Product Specific Information
Positive test controls include: 293T, U-251MG, HepG2, Mouse liver, Mouse brain.
Immunogen sequence:
RQFAMDAAAT AAAQRDTTLI RHSPQPSPSS SFNEGLLTGG HRHQEMESRL KVLHAQILEK DAVIKVLQQR SRRDPGKAIQ GSLRPAKSVP SVFAAAAAGT QGWQGLSSSE RQTADAPARL TTDRAPTEEP VVTAPPAAHA KHGSRDGSTQ TEGPPDSTST CLPPEPDSLL GCSSSQRAAS LDSVATSRVQ DLSDMVEILI
Target Information
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation, and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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