Thermo Fisher Scientific RTCA Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 93% · Dog: 100% · Guinea Pig: 100% · Horse: 93% · Human: 100% · Mouse: 86% · Rabbit: 100% · Rat: 93%

Target Information

RTCD1 catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.
The enzyme mechanism involves three steps:

1. Adenylation of the enzyme by ATP
2. The enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A
3. A non-catalytic nucleophilic attack by the adjacent 2'-hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product

The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. There are two named isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.