Thermo Fisher Scientific IRAK1 Recombinant Rabbit Monoclonal Antibody (1H5U0)
인간 IRAK1 단백질을 표적으로 하는 Thermo Fisher의 재조합 토끼 단클론 항체. Western blot 및 ELISA에 적합하며 높은 특이성과 재현성을 제공. HEK293 세포에서 발현된 IgG 형식, Protein A로 정제된 액상 항체.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1H5U0 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 215–499 of human IRAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.99 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
ELKIGEGGFG CVYRAVMRNT VYAVKRLKEN ADLEWTAVKQ SFLTEVEQLS RFRHPNIVDF AGYCAQNGFY CLVYGFLPNG SLEDRLHCQT QACPPLSWPQ RLDILLGTAR AIQFLHQDSP SLIHGDIKSS NVLLDERLTP KLGDFGLARF SRFAGSSPSQ SSMVARTQTV RGTLAYLPEE YIKTGRLAVD TDTFSFGVVV LETLAGQRAV KTHGARTKYL KDLVEEEAEE AGVALRSTQS TLQAGLAADA WAAPIAMQIY KKHLDPRPGP CPPELGLGLG QLACC
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Its association with MYD88 leads to phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. IRAK1 can also phosphorylate TIRAP to promote ubiquitination and degradation, and phosphorylates IRF7 to induce activation and nuclear translocation, resulting in transcriptional activation of type I IFN genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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