Thermo Fisher Scientific JMJD2C Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2664743

Product Specific Information

Immunogen sequence: ARFSTASDMRF EDTFYGADII QGERKRQRVL SSRFKNEYVA DPVYRTFLKS SFQKKCQK

Highest antigen sequence identity to the following orthologs - mouse 95%, rat 95%.

Target Information

Jumonji domain-containing protein 2C (JMJD2C)/ Lysine-specific demethylase 4C (KDM4C) is a histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3; thereby, playing a central role in histone code. KDM4C does not demethylate histone H3 Lys-4, H3 Lys-27, or H4 Lys-20. It demethylates trimethylated H3 Lys-9 and H3 Lys-36 residues. There is no activity on mono- or dimethylated residues. Demethylation of Lys residues generates formaldehyde and succinate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.