Thermo Fisher Scientific UCH37 Polyclonal Antibody
UCH37 단백질을 인식하는 Thermo Fisher의 토끼 다클론 항체로, Western blot과 면역세포염색에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며 항원 친화 크로마토그래피로 정제되었습니다. 암 연구 및 단백질 분해 조절 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human UCHL5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2720043 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein involved in editing polyubiquitinated protein substrates. UCH-L5 can rescue ubiquitinated proteins, including oncogenic ones, from proteasomal degradation, suggesting that deregulation may influence tumor growth. Through association with Smad7, UCH-L5 can upregulate TGFβ-dependent gene expression by deubiquitinating and stabilizing TGFβ RI. Overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in various cancer cell lines, indicating potential therapeutic interest. Four isoforms of UCH-L5 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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