Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI3G7), TrueMAB
인간 N4BP2L2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 최적화되어 있습니다. 무보존제, 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI3G7), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G7 |
| Immunogen | Full length human recombinant protein of human N4BP2L2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended desalting column: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5, is a 583 amino acid nuclear protein potentially involved in transcriptional regulation. It is phosphorylated on Ser199 in response to DNA damage, likely by ATM or ATR.
Primarily expressed in bone marrow, N4BP2L2 expression is significantly down-regulated after exposure to arsenic compounds, preceding neutropenia.
PFAAP5 interacts with Gfi-1 and Neutrophil Elastase (ELA2), proteins implicated in neutropenia disorders.
Defects in ELA2 cause cyclic haematopoiesis, characterized by reduced circulating neutrophils and increased susceptibility to opportunistic infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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