Thermo Fisher Scientific PSMD3 Monoclonal Antibody (OTI2A2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The 26S proteasome is a multicatalytic proteinase complex composed of a 20S core and a 19S regulator.

• The 20S core consists of four rings of 28 non-identical subunits (two α-rings and two β-rings).
• The 19S regulator includes a base with six ATPase subunits and two non-ATPase subunits, and a lid with up to ten non-ATPase subunits.
  Proteasomes are abundant in eukaryotic cells and degrade peptides in an ATP/ubiquitin-dependent manner.
  The immunoproteasome variant is essential for processing class I MHC peptides.
  The PSMD3 gene encodes one of the non-ATPase subunits of the 19S regulator lid.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.