Thermo Fisher Scientific ENO1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ENO1.

Target Information

Enolase (2-phosphogly-cerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phosphoenolpyruvate. It comprises three distinct subunits: alpha, beta, and gamma.
Non-neuronal Enolase (ENO1) is an isoform of mammalian enolase composed of two alpha subunits. The ENO1 gene also encodes a shorter monomeric structural lens protein, tau-crystallin.

This multifunctional enzyme plays roles in glycolysis, growth control, hypoxia tolerance, and allergic responses. It may function in the fibrinolytic system by acting as a receptor and activator of plasminogen on cell surfaces such as leukocytes and neurons. ENO1 stimulates immunoglobulin production and is used as a diagnostic marker for various tumors.

In its heterodimeric form (alpha/gamma), ENO1 serves as a marker for hypoxic brain injury after cardiac arrest and as a marker for endometriosis. Antibodies against alpha-enolase are found in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease linked to systemic tumor growth. ENO1 is also identified as an autoantigen in Hashimoto encephalopathy (HE), a rare autoimmune disease associated with Hashimoto thyroiditis (HT).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.