Thermo Fisher Scientific HOXA11 Polyclonal Antibody
HOXA11 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트, 영장류 반응성. 합성 펩타이드 면역원 사용, Affinity chromatography 정제, PBS/glycerol 완충액에 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HOXA11 (Accession P31270), corresponding to amino acid residues P137–P187 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20 °C |
| Shipping conditions | Wet ice |
| RRID | AB_2900012 |
Product Specific Information
Antibody detects endogenous levels of total HOXA11.
Target Information
HOX11 (also known as homeobox11 or Tcl-3) is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain containing protein with a glycine- and proline-rich amino terminus. HOX11 is required for the maintenance of the developing spleen and for cell survival. The HOX11 protein binds to a specific DNA sequence and localizes to the cell nucleus, acting as a positive transcription activator.
The HOX11 gene is highly expressed in T-ALLs due to chromosomal translocations such as t(7;10)(q35;q24) or t(10;14)(q24;q11). Deregulation of the homeobox gene upon translocation into the T-cell receptor locus activates a subset of tumor-associated target genes. HOX11 gene translocation has been linked to T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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