Thermo Fisher Scientific p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Monoclonal Antibody (DCS-72.F6)
세포 주기 조절 단백질 p27Kip1을 검출하는 Thermo Fisher Scientific의 단클론 항체로, WB, IHC, ICC, Flow 등 다양한 응용에 적합. 인간, 마우스, 랫 등 반응성 보유. 단클론 IgG1, kappa 형식으로 Protein A/G 정제, 액상 형태이며 4°C 보관.
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Thermo Fisher Scientific p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Monoclonal Antibody (DCS-72.F6)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.25–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DCS-72.F6 |
| Immunogen | Recombinant full-length Mouse p27 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFβ-induced G1 arrest. It is an important regulator of cell cycle progression and a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes.
p27 Kip1 forms a complex with cyclin D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation.
Depending on its phosphorylation state and stoichiometry, p27 Kip1 can act as either an inhibitor or activator of cyclin D-CDK4 complexes.
It has a molecular weight of approximately 27 kDa, and its degradation—triggered by CDK-dependent phosphorylation and subsequent ubiquitination by SCF complexes—is required for the cellular transition from quiescence to the proliferative state.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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