Thermo Fisher Scientific MCM7 Monoclonal Antibody (MCM7, 1466)
MCM7 단백질을 인식하는 Mouse monoclonal 항체로 Western blot 및 IHC(P) 실험에 적합합니다. Dog와 Human 시료에 반응하며, Protein A/G로 정제된 1 mg/mL 액상 형태입니다. PBS(pH 7.4)에 보존제가 없으며 -20°C 이하에서 보관합니다.
- 카탈로그번호
- 4176-MSM1-P1ABX
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MCM7, 1466 |
| Immunogen | Recombinant human MCM7 protein fragment (aa195–319) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C or –80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed):
Antibody incubation for 30 minutes at room temperature.
For formalin-fixed tissues, heat sections in 10 mM Tris with 1 mM EDTA (pH 9.0) at 95°C for 45 minutes, then cool at room temperature for 20 minutes.
Target Information
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in replication fork formation and recruitment of other DNA replication-related proteins.
The MCM complex, consisting of MCM2, MCM4, MCM6, and this protein, possesses DNA helicase activity and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase CDK4 associates with MCM7 and may regulate its interaction with tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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