Thermo Fisher Scientific HD Monoclonal Antibody (1D1)
Huntingtin 단백질을 표적하는 Thermo Fisher Scientific의 HD Monoclonal Antibody (1D1). 인간 시료 반응성, Mouse IgG2b 형식의 단일클론 항체. ICC/IF 및 ELISA에 사용 가능하며, Affinity chromatography로 정제된 액상 형태. 연구용으로만 사용.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 10 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D1 |
| Immunogen | HD (NP_002102, 1524–1627 a.a.) partial recombinant protein with GST tag (MW 26 KDa for GST tag alone) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
CDGIMASGRK AVTHAIPALQ PIVHDLFVLR GTNKADAGKE LETQKEVVVS MLLRLIQYHQ VLEMFILVLQ QCHKENEDKW KRLSRQIADI ILPMLAKQQM HIDS
Target Information
Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product.
HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10–20 years. The huntingtin locus spans 180 kb and consists of 67 exons.
The huntingtin gene is widely expressed and required for normal development. It exists as two alternatively polyadenylated forms with different abundance in fetal and adult tissues. The larger transcript (~13.7 kb) is predominantly expressed in brain, while the smaller (~10.3 kb) is more widely expressed.
The genetic defect leading to Huntington’s disease may not eliminate transcription but may alter mRNA or protein function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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