Thermo Fisher Scientific CrkRS Polyclonal Antibody
CrkRS 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot과 Immunoprecipitation에 적합합니다. 인간 CDC2 관련 kinase 영역(1-50 aa)에 대한 면역원으로 제작되었으며, 액상 형태로 4°C에서 보관합니다.
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Thermo Fisher Scientific CrkRS Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human cell division cycle 2 (CDC2)-related kinase arginine/serine-rich |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Predicted reactivity: Mouse and Rat (based on 100% sequence identity)
Target Information
CrkRS plays important functions in early cell signaling. It binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. It acts as an activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Although it has no intrinsic transcriptional activity, it activates transcription upon formation of JUN or FOS heterodimers. It can also bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter, while Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities, possibly by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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