Thermo Fisher Scientific CD14 Monoclonal Antibody (TuK4), APC-Alexa Fluor 750

Thermo Fisher Scientific CD14 Monoclonal Antibody (TuK4), APC-Alexa Fluor 750

Applications

• Flow Cytometry (Flow)

Tested Dilution: Assay-dependent
Publications: View 2 publications

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 647
• Alexa Fluor 700
• APC
• Biotin
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Cyanine5.5
• PE-Texas Red
• PerCP
• Qdot 655
• Qdot 705
• Qdot 800
• TRI-COLOR
• Request custom conjugation

Product Specific Information

The allophycocyanin (APC)-Alexa Fluor™ 750 dye tandem conjugate allows for multicolor measurements using excitation by lasers that emit from 633 to 650 nm.

Target Information

CD14 is a 55 kDa GPI-anchored glycoprotein expressed on mature monocytes, macrophages, and neutrophils. It functions as a lipopolysaccharide (LPS) receptor and is released into serum as both secreted and cleaved GPI-anchored forms. CD14 interacts with LPS via LBP (lipopolysaccharide-binding protein), aiding in immune response modulation. Soluble CD14 (sCD14) can distinguish structural differences between LPS molecules and plays a role in neutralizing foreign lipopolysaccharides. It also binds apoptotic cells and influences allergic, inflammatory, and infectious processes. Alternative splicing produces multiple transcript variants encoding the same CD14 isoform. CD14 dysfunction is associated with mycobacterium chelonae infection and croup.

Classification

Analyte Specific Reagent

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