Thermo Fisher Scientific B4GALT1 Recombinant Rabbit Monoclonal Antibody (001)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

• This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits.
• Advantages include better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to the larger rabbit immune repertoire.
• This antibody has specificity for Human B4GALT1/GGTB2.

Target Information

B4GALT1 is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes encoding type II membrane-bound glycoproteins with specificity for UDP-galactose. These enzymes transfer galactose in a beta1,4 linkage to acceptor sugars such as GlcNAc, Glc, and Xyl.
Each beta4GalT has distinct functions in glycoconjugate biosynthesis. As type II membrane proteins, they possess an N-terminal hydrophobic sequence directing them to the Golgi apparatus, serving as a transmembrane anchor.
B4GALT1 uniquely participates in both glycoconjugate and lactose biosynthesis. In lactating mammary tissues, it forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose ⇔ UDP + lactose.
The enzyme’s dual activities result from alternate transcription initiation and post-translational processing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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