Thermo Fisher Scientific CCP110 Polyclonal Antibody
CCP110 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC(P), ICC/IF에 사용 가능. 인간, 마우스, 원숭이, 랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CCP110 (Accession O43303), corresponding to amino acid residues A866–Q916 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853058 |
Product Specific Information
Antibody detects endogenous levels of total CEP110.
Target Information
CCP110 is necessary for centrosome duplication during procentriole formation. It acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole, preventing cilia formation. It also plays a role in promoting ciliogenesis and assembly of mother centriole subdistal appendages (SDA), affecting recycling endosome fusion to basal bodies during cilia formation. Additionally, CCP110 is required for correct spindle formation and contributes to cytokinesis and genome stability via cooperation with CALM1 and CETN2. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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