Thermo Fisher Scientific P-Glycoprotein Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

• Positive Samples: Mouse brain
• Cellular Location: Cell membrane, Multi-pass membrane protein
• Immunogen Sequence:
  STVRNADVIA GFDDGVIVEK GNHDELMKEK GIYFKLVTMQ TAGNEVELEN AADESKSEID ALEMSSNDSR SSLIRKRSTR RSVRGSQAQD RKLSTKEALD

Target Information

The membrane-associated protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across cell membranes and are grouped into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is part of the MDR/TAP subfamily and functions as an ATP-dependent efflux pump for xenobiotic compounds, contributing to multidrug resistance. It reduces intracellular drug accumulation and mediates resistance to anticancer drugs. Additionally, it serves as a transporter in the blood-brain barrier.

주의사항

⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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