Thermo Fisher Scientific GABRR1 Polyclonal Antibody
Rabbit polyclonal antibody against human GABRR1. Validated for WB and ICC/IF applications. Detects endogenous total GABRR1 protein. Supplied as liquid, 1 mg/mL in PBS with 50% glycerol. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GABRR1 (Accession P24046), corresponding to amino acid residues S213–S263 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853181 |
Product Specific Information
Antibody detects endogenous levels of total GABRR1.
Target Information
GAD-65 and GAD-67 are glutamate decarboxylases that catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system, GABA functions as the main inhibitory neurotransmitter by increasing Cl⁻ conductance, which inhibits neuronal firing. GABA activates ionotropic (GABAA) and metabotropic (GABAB) receptors, as well as a third class, GABAC receptors.
GABAC receptors mediate rapid inhibitory neurotransmission in the retina. Three human genes—GABRR1, GABRR2, and GABRR3—encode the receptor subunits. GABRR1 and GABRR2 are located on chromosome 6q, while GABRR3 is found on chromosome 3q11–q13.3. These genes share a common ancestor with GABAA receptor subunit genes and diverged early in evolution. Although highly expressed in the retina, GABAC receptor subunits are also found in other brain regions, particularly within the visual pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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