Thermo Fisher Scientific TBL1XR1 Monoclonal Antibody (OTI2A8), TrueMAB
TBL1XR1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western Blot에 적합합니다. 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 안정적인 보관용 버퍼 포함.
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Thermo Fisher Scientific TBL1XR1 Monoclonal Antibody (OTI2A8), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:2,000
Species Reactivity
- Human
- Mouse
- Rat
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A8 |
| Immunogen | Full length human recombinant protein of human TBL1XR1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) participate in diverse transcriptional repression pathways.
N-CoR and SMRT exist in large protein complexes that recruit histone deacetylases (HDACs) to form repressive chromatin. HDAC3 is the main HDAC associated with N-CoR and SMRT complexes and is essential for repression.
TBLR1 is a WD-40 repeat protein that also associates with these complexes. Although TBLR1 is a core component of both N-CoR and SMRT complexes, its precise role remains to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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