Thermo Fisher Scientific HLA-DR Monoclonal Antibody (TU36), FITC

Thermo Fisher Scientific HLA-DR Monoclonal Antibody (TU36), FITC

Applications

• Flow Cytometry (Assay-dependent)

Publications

• Flow Cytometry: 7 publications
• Miscellaneous (PubMed): 5 publications

Product Specifications

Additional Formats

• APC
• Pacific Blue
• Pacific Orange
• PE
• PE-Cyanine5.5
• PE-Texas Red
• PerCP
• Qdot 605
• Qdot 655
• Qdot 705
• Custom conjugation available

Product Specific Information

FITC conjugates provide high absorptivity, excellent fluorescence quantum yield, and good water solubility, making them suitable for flow cytometry and fluorescence-based assays.

Target Information

HLA-DR is a major histocompatibility complex (MHC) class II molecule composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).

• The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
• DRA lacks polymorphisms in the peptide-binding region and serves as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.
• The beta chain contains polymorphisms defining peptide-binding specificity, and numerous DRB1 alleles are used in transplantation typing.
• HLA-DR is expressed on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
• DR, DQ, and DP loci encode major human class II MHC molecules, which bind intracellularly processed peptides and present them to T-helper cells, playing a crucial role in immune response initiation.

HLA and MHC antibodies are essential tools in Immunopeptidomics, supporting neoantigen identification and characterization via HPLC-MS/MS.

Analyte Specific Reagent

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