Thermo Fisher Scientific alpha Internexin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

In Western blot, a band at approximately 66 kDa is detected. Minor bands of around 50 kDa and 150 kDa are also observed, which likely correspond to alpha-internexin breakdown products and covalent dimers, respectively.

Target Information

Alpha-internexin is a Class IV intermediate filament subunit expressed early in neuronal development. It is related to, but distinct from, the neurofilament triplet proteins (NF-L, NF-M, NF-H), sharing similar sequence motifs and intron organization. Many mature neurons contain alpha-internexin along with NF-L, NF-M, and NF-H, while some express only alpha-internexin.
Antibodies against alpha-internexin serve as valuable tools for studying and classifying neuronal types and tracing neuronal processes in tissue sections or cultures. Its early developmental expression makes it a useful marker for neuronal progenitor cells and cells committed to the neuronal lineage.
Although its use in brain tumor studies has not yet been explored, it may hold potential interest.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.