Thermo Fisher Scientific PAI1 Monoclonal Antibody (1D5)
PAI1 단백질을 타겟으로 하는 Thermo Fisher Scientific의 단클론 항체(1D5). Western blot, IHC, ELISA 등 다양한 응용에 적합하며, Human 및 Mouse 시료에 반응. Protein G 정제, 1 mg/mL 농도의 액상 형태로 제공.
- 카탈로그번호
- MA517171
- 판매단위
- pk
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PAI1 Monoclonal Antibody (1D5)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 3 publications |
| Immunohistochemistry (IHC) | – | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:1,000 | – |
| Flow Cytometry (Flow) | 1:200–1:400 | – |
| ELISA | 1:10,000 | – |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D5 |
| Immunogen | Purified recombinant fragment of human SERPINE1 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538642 |
Product Specific Information
MA5-17171 targets SERPINE1 in FACS, IHC, indirect ELISA, and WB applications and shows reactivity with Human samples.
The immunogen is a purified recombinant fragment of human SERPINE1 expressed in E. coli.
MA5-17171 detects SERPINE1, which has a predicted molecular weight of approximately 45 kDa.
Target Information
PAI1 (plasminogen activator inhibitor 1) belongs to the serine protease inhibitor superfamily and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA).
Platelets are the main source of circulating PAI1, but it is also synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells.
Expression of PAI1 can be regulated by various factors such as growth factors, cytokines, hormones, inflammatory mediators, glucose or lipid metabolites, and environmental or physical stimuli.
Elevated PAI1 levels are associated with increased thrombosis risk in obesity, thrombophilia, and metabolic syndrome.
Defects in PAI1 are linked to abnormal bleeding and fibrinolysis inhibition disorders, including plasminogen activator inhibitor-1 deficiency.
Alternatively spliced transcript variants encoding different isoforms of PAI1 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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