Thermo Fisher Scientific PHAP III Polyclonal Antibody
Thermo Fisher Scientific의 PHAP III Polyclonal Antibody는 인간 PHAP 단백질을 인식하는 토끼 다클론 항체로, Western blot과 IHC에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 액상 형태로 제공되어 안정적입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.25 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
| CUT&RUN (C&R) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human ANP32E |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2605727 |
Product Specific Information
Peptide sequence:
EDNEAPDSEE EDDEDGDEDD EEEEENEAGP PEGYEEEEEE EEEEDEDEDE
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 93%
Horse: 100%
Human: 100%
Mouse: 93%
Rabbit: 100%
Rat: 100%
Yeast: 82%
Zebrafish: 79%
Target Information
Apoptosis is related to many diseases and developmental processes. Caspase-9 plays a central role in cell death induced by various apoptosis activators. When cytochrome c is released from mitochondria, it binds to Apaf-1 to form an apoptosome, which activates procaspase-9. Activated caspase-9 subsequently activates effector caspases (caspase-3, -6, and -7), leading to proteolytic cleavage of key proteins during apoptosis.
PHAP proteins, including PHAP III, have been identified as important regulators of mitochondrial apoptosis. PHAP facilitates apoptosome-mediated caspase-9 activation and stimulates the mitochondrial apoptotic pathway. It also opposes Ras- and Myc-mediated cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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