Thermo Fisher Scientific Phospho-ASK1 (Thr845) Polyclonal Antibody
Phospho-ASK1 (Thr845) 단백질을 검출하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. Human 시료에 반응하며, Affinity chromatography로 정제되었습니다. 연구용으로 사용되며 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around T845 of mouse MAP3K5 (NP_0326064) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.51 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901903 |
Product Specific Information
- Positive Samples: 293T
- Immunogen sequence: TETFT
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated by various extracellular stimuli, including cytokines, growth factors, and environmental stresses.
ASK1 (Apoptosis Signal-regulating Kinase 1), also known as MAPKKK5, activates MKK4 and MKK6, which subsequently activate JNK and p38 MAP kinases.
ASK1 is activated by TNFR and Fas through interaction with TRAF family members and Daxx. Overexpression induces apoptosis, while catalytically inactive ASK1 inhibits TNF-α-induced apoptosis. ASK1 is expressed in various human and mouse tissues.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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